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Asgi Fazleabas Asgi Fazleabas, PhD

Distinguished Prof. and Associate Chair for Research,
Department of OB/GYN R B, Michigan State Univ.

Asgi Fazleabas is a University Distinguished Professor and Associate Chair for Research in the Department of Obstetrics, Gynecology and Reproductive Biology and the Director of the MSU Center for Women’s Health Research. His research laboratory, which is funded by the National Institutes of Health, is focused on understanding the basic biology of endometriosis. Current studies in his laboratory are focused on the inflammatory signals mediated by the cytokine IL-6 to regulate NOTCH1 signaling. NOTCH1 is overexpressed in endometriotic lesions in both baboons and women with endometriosis, suggesting that the NOTCH1 signaling pathway actively promotes endometriotic lesion development. The studies demonstrate that direct binding of the E- protein transcription factors E2A and HEB that are induced by IL-6, which is present in the inflammatory peritoneal environment and secreted primarily by ectopic tissues, up-regulate NOTCH1. The increase in NOTCH1, in turn, promotes endometriotic lesion development by controlling cell proliferation and invasion and provides a novel mechanism for targeted therapy.

Asgi Fazleabas, PhD - NOTCH1 Mediated Inflammation in Ectopic Lesions: Opportunities for Targeted Therapy

Asgi Fazleabas, PhD - NOTCH1 Mediated Inflammation in Ectopic Lesions: Opportunities for Targeted Therapy

Asgi Fazleabas, PhD - NOTCH1 Mediated Inflammation in Ectopic Lesions: Opportunities for Targeted Therapy Endometriosis Foundation of AmericaMedical Conference 2019Targeting Inflammation:From Biomarkers to Precision SurgeryMarch 8-9, 2019 -…

Asgi Fazleabas, PhD - The role of microRNAs in the pathophysiology of endometriosis

Asgi Fazleabas, PhD - The role of microRNAs in the pathophysiology of endometriosis

Asgi Fazleabas, PhD The role of microRNAs in the pathophysiology of endometriosis Scientific Symposium Advancing the Science and Surgery of EndometriosisMonday and Tuesday, April 18-19, 2016The Union Club, New York Thank you so much and again…

Asgi Fazleabas - Primate Models for Endometriosis Research - do miRNAs play a role?

Asgi Fazleabas - Primate Models for Endometriosis Research - do miRNAs play a role?

Endofound’s Sixth Annual Medical Conference: Ending Endometriosis Starts at the Beginning Primate Models for Endometriosis Research - do miRNAs play a role? Asgi Fazleabas, MD

Asgi Fazleabas MD, PhD - Medical Conference 2014

Asgi Fazleabas MD, PhD - Medical Conference 2014

Endometriosis Foundation of America 2014        18How valuable are animal models for endometriosis and what can they teach us?- Asgi Fazleabas. Md, PhDThank you Bill and thank you Tamer for the invitation. This…